BIPHENYL DERIVATIVE

PURPOSE:To obtain a new biphenyl derivative, having vasopressin antagonistic action and useful as a water diuretic, an anticardiac failure and an antihypertensive agents. CONSTITUTION:The compound of formula I [either of R and R is H and the other is H, amino or mono- or di-lower alkylamino or R and...

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Bibliographische Detailangaben
Hauptverfasser:	KIKUCHI KAZUMI, YANAGISAWA ISAO, TANITSU TAKEYUKI, MATSUMOTO YUZO, TANAKA AKIHIRO, SHIMADA YOSHIAKI, MATSUHISA AKIRA
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PURPOSE:To obtain a new biphenyl derivative, having vasopressin antagonistic action and useful as a water diuretic, an anticardiac failure and an antihypertensive agents. CONSTITUTION:The compound of formula I [either of R and R is H and the other is H, amino or mono- or di-lower alkylamino or R and R together form carbonyl; R is H, OH, lower alkyl, lower alkoxy or lower alkanoyloxy; X is CH2 or NR (R is H, lower alkyl or lower alkanoyl)], e.g. 1-(biphenyl-4- ylcarbonyl)-2,3,4,5-tetrahydro-1H-benzazepine. This compound is obtained by reacting a compound of formula II with a compound of formula III (Y is carboxyl or its reactive derivative) according to usual reaction for forming amide bond.