NEW PHENYLGLYCOSIDE

PURPOSE:To provide a new phenylglycoside having excellent activity to suppress the isolation of histamine from mast cell and, accordingly, useful as a new antiallergic agent effective for suppressing the isolation of histamine itself from mast cell. CONSTITUTION:The phenylglycoside of formula I [X i...

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Bibliographische Detailangaben
Hauptverfasser:	KAKEGAWA TOSHIO, SATO TOSHIO, NIINO YASUNORI, MATSUMOTO HITOSHI
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	PURPOSE:To provide a new phenylglycoside having excellent activity to suppress the isolation of histamine from mast cell and, accordingly, useful as a new antiallergic agent effective for suppressing the isolation of histamine itself from mast cell. CONSTITUTION:The phenylglycoside of formula I [X is sugar residue obtained by removing all hydroxyl groups from a sugar having (n+1) hydroxyl groups; (n) is 3 or 4; R is 9-18C alkyl], e.g. 4-decyloxyphenyl-beta-D-glycopyranoside. The compound can be produced by the deacetylation of the compound of formula II The compound of formula II is obtained e.g. by reacting a monoalkylhydroquinone of formula III with a peracetylated sugar of formula IV in a non-aqueous solvent (e.g. benzene) in the presence of an organic solvent complex of a Lewis acid as a catalyst. The organic acid complex of Lewis acid is e.g. BF3.ether.