TRICYCLIC COMPOUND

PURPOSE:To provide a new tricyclic compound useful as an anti-histaminic agent or anti-allergic agent reduced in the side effects and having excellent selectivity. CONSTITUTION:A tricyclic compound of formula I (X is CH=CH, CH2O, O; R is lower alkyl; R is H, lower alkyl; (n) is 1-5) and its salt. Fo...

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Hauptverfasser:	SAWANISHI HIROYUKI, OGAWA NOBUO, ECCHU EIICHI, MORIKAWA KOJI, ITO YASUO, KATO HIDEO
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	SAWANISHI HIROYUKI OGAWA NOBUO ECCHU EIICHI MORIKAWA KOJI ITO YASUO KATO HIDEO
description	PURPOSE:To provide a new tricyclic compound useful as an anti-histaminic agent or anti-allergic agent reduced in the side effects and having excellent selectivity. CONSTITUTION:A tricyclic compound of formula I (X is CH=CH, CH2O, O; R is lower alkyl; R is H, lower alkyl; (n) is 1-5) and its salt. For example, [N-[3-(5H-benzo[a,b]cyclophepten-5-ylidene)prpyl]-N-methylamino]acetic acid ethyl ester. The compound is obtained by reacting a compound of formula II with a compound of formula III or IV (Y is halogen) at 0-200 deg.C and, if necessary, hydrolyzing the reaction product with an acid or base in a solvent. The raw material of formula II includes 5-[3-(methylamino)propylindene]-5H- dibenzo[a,b]cycloheptene.
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CONSTITUTION:A tricyclic compound of formula I (X is CH=CH, CH2O, O; R is lower alkyl; R is H, lower alkyl; (n) is 1-5) and its salt. For example, [N-[3-(5H-benzo[a,b]cyclophepten-5-ylidene)prpyl]-N-methylamino]acetic acid ethyl ester. The compound is obtained by reacting a compound of formula II with a compound of formula III or IV (Y is halogen) at 0-200 deg.C and, if necessary, hydrolyzing the reaction product with an acid or base in a solvent. 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CONSTITUTION:A tricyclic compound of formula I (X is CH=CH, CH2O, O; R is lower alkyl; R is H, lower alkyl; (n) is 1-5) and its salt. For example, [N-[3-(5H-benzo[a,b]cyclophepten-5-ylidene)prpyl]-N-methylamino]acetic acid ethyl ester. The compound is obtained by reacting a compound of formula II with a compound of formula III or IV (Y is halogen) at 0-200 deg.C and, if necessary, hydrolyzing the reaction product with an acid or base in a solvent. The raw material of formula II includes 5-[3-(methylamino)propylindene]-5H- dibenzo[a,b]cycloheptene.</abstract><oa>free_for_read</oa></addata></record>
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subjects	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	TRICYCLIC COMPOUND
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