JPH0569508B

JPH0569508B

A novel urokinase of the formula: R-CO-NH urokinase wherein R is the residue of a water-soluble homo- or copolymer with a molecular weirht of 2,000 to 10,000, can be produced by reacting a carbonylimidazole derivative of the formula: with urokinase in a buffer solution at pH 6 to 11. The product is...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KURONO MASATSUNE, SAWAI KIICHI, IWATA TADAHIKO, AWATANI JUICHI
Format: Patent
Sprache:eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:A novel urokinase of the formula: R-CO-NH urokinase wherein R is the residue of a water-soluble homo- or copolymer with a molecular weirht of 2,000 to 10,000, can be produced by reacting a carbonylimidazole derivative of the formula: with urokinase in a buffer solution at pH 6 to 11. The product is resistible to urokinase inhibitors, highly stable in blood and serves as a thrombolytic agent having durable effect.