THERAPEUTIC AGENT FOR HEPATOPATHY

PURPOSE:To obtain the subject therapeutic agent for hepatopathy, especially hepatitis comprising a pyrimidine derivative as an active ingredient. CONSTITUTION:The objective therapeutic agent is obtained by including a compound of formula I (R and R are H, straight-chain or branched lower alkyl, substitutable phenyl or cyclohexyl; R is straight-chain or branched lower alkyl;-indicates that a stereoisomer is included) or its pharmacologically permissible salt, e.g. 1-methyl-3-phenyl-5-(3,5-di-t-butyl-4-hydroxy-benzylidene)- pyrimidin-2,4,6-trione as an active ingredient. Although this medicinal pharmaceutical can be used in the form of an oral or a parenteral medicine or a medicine for external use, it is preferably used as the oral medicine. The compound of formula I is obtained by reacting a compound of formula II with a compound of formula III.