PYRIDAZINE DERIVATIVE

PURPOSE:To provide a new pyridazine derivative useful for hypertension, congestive heat failure and chronic renal disease. CONSTITUTION:A compound of formula I [R to R are H, 1-6C alkyl, (CH2)mX is 0-3; X is halogen, cyano, etc.,), etc.; R'' is carboxyl, sulfonic acid, P2O5, etc.,] and its...

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Bibliographische Detailangaben
Hauptverfasser:	MATSUMOTO HIROO, MASUDA YUKINORI, KAMIKAWAJI MASUMASA, IKUYORI KAZUHIKO, OODOI KEISUKE, SETO KIYOTOMO, HIGASHIYAMA TSUTOMU
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PURPOSE:To provide a new pyridazine derivative useful for hypertension, congestive heat failure and chronic renal disease. CONSTITUTION:A compound of formula I [R to R are H, 1-6C alkyl, (CH2)mX is 0-3; X is halogen, cyano, etc.,), etc.; R'' is carboxyl, sulfonic acid, P2O5, etc.,] and its tautomer and its salt, e.g. 4,5-dichloro-1,6-dihydro-1-[(2'-(N- triphenylmethyl-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-6-oxopyridazine. The compound of formula I is obtained e.g. by reacting a compound of formula II with a compound of formula III (V is Cl, Br, I, etc.; R is carboxyl, sulfonyl, etc., which may be protected with methyl, ethyl, etc.,) in the presence of an inorganic base such as sodium carbonate in a ketone solvent at 0 deg.C to the boiling point of the solvent and subsequently removing the protecting agent from the reaction product.