UREA DERIVATIVE

PURPOSE:To provide a new urea derivative having ACAT enzyme-inhibitory activity and excellent reducing activity for blood total cholesterol and low- specific gravity lipoprotein, for preventing and curing cerebral infarction, transient ischemic attack, stenocardia, peripheral thrombosis and obliterans, etc. CONSTITUTION:The objective compound of formula I (R is fluorenyl or phenanthrenyl; R is cycloalkyl; R is lower alkoxy-substituted phenyl; A is lower alkylene) or its salt, e.g. 1-cycloheptyl-1-[(2-fluorenyl)methyl]-3-(2,4,6- trimethoxyphenyl)urea. The compound of the formula I can be obtained, for example, by reaction of an amino compound of formula IV with a carboxyhalogen compound of formula III (X is halogen; R is phenyl or lower alkyl) to produce a carbamate, which is then made to react with a compound of formula II. The compound of the formula I is characterized by binding, via alkylene group, to condensed carbon ring.