PRODUCTION PROCESS FOR IODOSOBENZOIC ACID

PURPOSE:To obtain the subject compound which is used as an oxidizing agent, a synthetic intermediate or a reagent for studying protein, by oxidizing an alkali iodobenzoate with an oxidizing agent such as alkali hypochlorite or bleaching powder or with chlorine in the presence of an alkali hydroxide. CONSTITUTION:Iodobenzoic acid such as o-iodobenzoic acid is dissolved using sodium hydroxide and water to form sodium iodobenzoate. The salt is oxidized with an alkali hypochlorite such as sodium hypochlorite or bleaching powder or with chlorine in the presence of an alkali hydroxide such as sodium hydroxide. Then, the reaction mixture is acidified by adding acetic acid or the like to precipitate solid, heated at 60 to 100 deg.C, the formed crystals are filtered off, rinsed with water, dried to give the objective iodosobenzoic acid in high yield.