PHENETYL ALCOHOL GLYCOSIDE AND LIPOPEROXIDE PRODUCTION-INHIBITORY AGENT WITH THE SAME AS ACTIVE INGREDIENT

NEW MATERIAL:A phenetyl alcohol glycoside of the formula (R1 and R2 are each H or CH3). USE:A medicine. An active ingredient for lipoperoxide production-inhibitory agents. Having lipoperoxide production-inhibitory activity effective for the therapies of circulatory diseases, low toxic and high in sa...

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Hauptverfasser: SASAKI HIROSHI, INAGAKI NOBUYUKI, YANAGISAWA TOSHIHIKO, NISHIMURA HIROAKI
Format: Patent
Sprache:eng
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Zusammenfassung:NEW MATERIAL:A phenetyl alcohol glycoside of the formula (R1 and R2 are each H or CH3). USE:A medicine. An active ingredient for lipoperoxide production-inhibitory agents. Having lipoperoxide production-inhibitory activity effective for the therapies of circulatory diseases, low toxic and high in safety. The dosage as a peroral agent is 50mg to 5g/kg adult body weight/time, its administration should be made in several portions a day. PREPARATION:The portions of Stachys riederi above the ground, mainly its leaves are extracted with water, an alcohol, mixed solvent thereof or mixed solvent of water and acetone, and the solvent is removed from the resulting extract solution to obtain a residue. This residue is either directly, or, after removing the liposoluble components therein by extracting it with an organic solvent such as petroleum ether, extracted with n-butanol, and the solvent is removed from the resulting extract solution into a residue, which is then put to column chromatography several times and fractionated, thus obtaining the objective glycoside.