PRODUCTION OF L-GLUTAMIC ACID BY FERMENTATION METHOD

PURPOSE:To industrially and inexpensively obtain the subject compound by culturing a variant belonging to the genus Brevibacterium or Corynebacterium, capable of producing L-glutamic acid, and having resistance to antibiotics with inhibitory action on cell wall synthesis. CONSTITUTION:A variant [e.g...

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Bibliographische Detailangaben
Hauptverfasser:	KAWAHARA YOSHIO, IMAIZUMI KOICHI, MURAKAMI YUTAKA
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES USING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PURPOSE:To industrially and inexpensively obtain the subject compound by culturing a variant belonging to the genus Brevibacterium or Corynebacterium, capable of producing L-glutamic acid, and having resistance to antibiotics with inhibitory action on cell wall synthesis. CONSTITUTION:A variant [e.g.Brevibacterium lactofermentum-vancomcin resistant variant AJ12,557 (FERM P-11,730)] belonging to the genus Brevibacterium or Corynebacterium, capable of producing L-glutamic acid, and having resistance to antibiotics with inhibitory action on cell wall synthesis, is inoculated into a medium having an osmotic pressure of 2,000-4,000 mOSm/kg.H2O which is higher than a common medium in L-glutamic acid fermentation, subjected to shaking culture at 31.5 deg.C, L-glutamic acid is formed and accumulated in the culture solution and collected to give the objective L-glutamic acid.