OXALYLAMINO ACID DERIVATIVE, METHOD OF ITS PREPARATION AND ITS USE AS DRUG FOR INHIBITION OF PROLINE HYDROXYLASE
PURPOSE: To provide an oxalylamino acid derivative useful as a medicine for inhibiting proline hydroxylase and lysine hydroxylase. CONSTITUTION: This oxalylamino acid derivative is a compound of the formula [R and R' are each a 1-6C alkyl or H; R is H or a 1-4C alkyl; R is H, a 1-6C alkyl, a 1-...
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| creator | FUORUKUMARU GIYUNTSURAA PUKARU EKEHARUTO BAADAA HAARARUTO BURUKUHARUTO |
| description | PURPOSE: To provide an oxalylamino acid derivative useful as a medicine for inhibiting proline hydroxylase and lysine hydroxylase. CONSTITUTION: This oxalylamino acid derivative is a compound of the formula [R and R' are each a 1-6C alkyl or H; R is H or a 1-4C alkyl; R is H, a 1-6C alkyl, a 1-3C alkoxy, carboxyl, a 1-6C alkoxycarbonyl, an aryl, SH, NH2 or a halogen (with the proviso that the alkyl can be substituted by an aryl, O, H, SH or NH2 ); both R and R form a 2-4C alkylene chain by bonding each other], a D- or L-form compound thereof and a salt thereof, e.g. (N-oxalyl)- L-alanine dimethyl ester. A preparation includes the oxalylamino acid derivative as an active ingredient. The preparation is useful as a medicament having activities for inhibiting fiberization and/or immunity, or affecting metabolism of collagen and a collagen-like material or biosynthesis of C1q. |
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CONSTITUTION: This oxalylamino acid derivative is a compound of the formula [R and R' are each a 1-6C alkyl or H; R is H or a 1-4C alkyl; R is H, a 1-6C alkyl, a 1-3C alkoxy, carboxyl, a 1-6C alkoxycarbonyl, an aryl, SH, NH2 or a halogen (with the proviso that the alkyl can be substituted by an aryl, O, H, SH or NH2 ); both R and R form a 2-4C alkylene chain by bonding each other], a D- or L-form compound thereof and a salt thereof, e.g. (N-oxalyl)- L-alanine dimethyl ester. A preparation includes the oxalylamino acid derivative as an active ingredient. 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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | OXALYLAMINO ACID DERIVATIVE, METHOD OF ITS PREPARATION AND ITS USE AS DRUG FOR INHIBITION OF PROLINE HYDROXYLASE |
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