AMIDE COMPOUND, ITS PHARMACEUTICAL USE AND NEW 1-SUBSTITUTED PYRROLIDINEMETHYLAMINES
PURPOSE:To obtain a new amide compound useful for treating psychosomatic diseases and phrenopathy. CONSTITUTION:An amide compound expressed by formula I {R is 1-4C alkoxy; R is H or R and R are bonded to form oxyethylene; R is S(O)mR [R is 1-4C alkyl or phenylalkyl; (m) is 0-2] or SO2NR R (R and R a...
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| creator | IKEBE TSUGIO MURAKAMI OSAMU MORIMOTO YASUTO TAKEHARA SHUZO |
| description | PURPOSE:To obtain a new amide compound useful for treating psychosomatic diseases and phrenopathy. CONSTITUTION:An amide compound expressed by formula I {R is 1-4C alkoxy; R is H or R and R are bonded to form oxyethylene; R is S(O)mR [R is 1-4C alkyl or phenylalkyl; (m) is 0-2] or SO2NR R (R and R are H or 1-4C alkyl); R is 6-15C alkyl} and its salt or optical isomer thereof, e.g. (S)-N-[(1- hexyl-2-pyrrolidinyl)methyl]2-methoxy-5-sulfamoylbenzamide. The af orementioned compound is obtained by reacting a carboxylic acid expressed by formula II or its reactive derivative with a 1-substituted pyrrolidine-2- methylamines expressed by formula III. The resultant compound is useful as an antischizophrenic agent, a therapeutic agent for dystropy, emotional disorder, etc., a medicine such as an inhibitor for psychosomatic diseases or emesis, a therapeutic agent for diarrhea originating from stress, tension of feeling, etc., and indefinite complaint of alimentary systems. |
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CONSTITUTION:An amide compound expressed by formula I {R is 1-4C alkoxy; R is H or R and R are bonded to form oxyethylene; R is S(O)mR [R is 1-4C alkyl or phenylalkyl; (m) is 0-2] or SO2NR R (R and R are H or 1-4C alkyl); R is 6-15C alkyl} and its salt or optical isomer thereof, e.g. (S)-N-[(1- hexyl-2-pyrrolidinyl)methyl]2-methoxy-5-sulfamoylbenzamide. The af orementioned compound is obtained by reacting a carboxylic acid expressed by formula II or its reactive derivative with a 1-substituted pyrrolidine-2- methylamines expressed by formula III. The resultant compound is useful as an antischizophrenic agent, a therapeutic agent for dystropy, emotional disorder, etc., a medicine such as an inhibitor for psychosomatic diseases or emesis, a therapeutic agent for diarrhea originating from stress, tension of feeling, etc., and indefinite complaint of alimentary systems.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1992</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19920814&DB=EPODOC&CC=JP&NR=H04225954A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19920814&DB=EPODOC&CC=JP&NR=H04225954A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>IKEBE TSUGIO</creatorcontrib><creatorcontrib>MURAKAMI OSAMU</creatorcontrib><creatorcontrib>MORIMOTO YASUTO</creatorcontrib><creatorcontrib>TAKEHARA SHUZO</creatorcontrib><title>AMIDE COMPOUND, ITS PHARMACEUTICAL USE AND NEW 1-SUBSTITUTED PYRROLIDINEMETHYLAMINES</title><description>PURPOSE:To obtain a new amide compound useful for treating psychosomatic diseases and phrenopathy. 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CONSTITUTION:An amide compound expressed by formula I {R is 1-4C alkoxy; R is H or R and R are bonded to form oxyethylene; R is S(O)mR [R is 1-4C alkyl or phenylalkyl; (m) is 0-2] or SO2NR R (R and R are H or 1-4C alkyl); R is 6-15C alkyl} and its salt or optical isomer thereof, e.g. (S)-N-[(1- hexyl-2-pyrrolidinyl)methyl]2-methoxy-5-sulfamoylbenzamide. The af orementioned compound is obtained by reacting a carboxylic acid expressed by formula II or its reactive derivative with a 1-substituted pyrrolidine-2- methylamines expressed by formula III. The resultant compound is useful as an antischizophrenic agent, a therapeutic agent for dystropy, emotional disorder, etc., a medicine such as an inhibitor for psychosomatic diseases or emesis, a therapeutic agent for diarrhea originating from stress, tension of feeling, etc., and indefinite complaint of alimentary systems.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | AMIDE COMPOUND, ITS PHARMACEUTICAL USE AND NEW 1-SUBSTITUTED PYRROLIDINEMETHYLAMINES |
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