AMIDE COMPOUND, ITS PHARMACEUTICAL USE AND NEW 1-SUBSTITUTED PYRROLIDINEMETHYLAMINES

PURPOSE:To obtain a new amide compound useful for treating psychosomatic diseases and phrenopathy. CONSTITUTION:An amide compound expressed by formula I {R is 1-4C alkoxy; R is H or R and R are bonded to form oxyethylene; R is S(O)mR [R is 1-4C alkyl or phenylalkyl; (m) is 0-2] or SO2NR R (R and R are H or 1-4C alkyl); R is 6-15C alkyl} and its salt or optical isomer thereof, e.g. (S)-N-[(1- hexyl-2-pyrrolidinyl)methyl]2-methoxy-5-sulfamoylbenzamide. The af orementioned compound is obtained by reacting a carboxylic acid expressed by formula II or its reactive derivative with a 1-substituted pyrrolidine-2- methylamines expressed by formula III. The resultant compound is useful as an antischizophrenic agent, a therapeutic agent for dystropy, emotional disorder, etc., a medicine such as an inhibitor for psychosomatic diseases or emesis, a therapeutic agent for diarrhea originating from stress, tension of feeling, etc., and indefinite complaint of alimentary systems.