NEW ANTIVIRAL PEPTIDE

Peptides of formula (I) and their salts are new. W = an amino protecting group or CO-R3; R3 = H, linear or branched at least 8C alkyl or 6-10C aryl (opt. substd. by halogen, OH, NO2, CF3 or linear or branched alkyl or alkoxy with at least 8C); A,B,D,E and L = a direct bond, a cyclic amino acid residue of formula (i) or NR4-CHR5-(CH2)p-CO; p = 0-2; m = 1-2; R4 = H, linear or branched at least 8C alkyl or phenyl; R5 = 3-8C cycloalkyl or 6-10C aryl or H or at least 8C linear or branched alkyl (opt. substd. by 3-8C cycloalkyl or 6-10C aryl opt. substd. by OH, halogen, NO2, at least 8C alkoxy or NR6R7), or by a 5-6 membered micro-contg. heterocycle or indolyl (in which the micro atom is opt. substd. by at least 6C alkyl or is amino-protected or opt. substd. by at least 6C alkylthio, OH, SH, guanidyl, NR6R7 or -CO-R8; R6, R7 = H, linear or branched at least 8C alkyl or phenyl; R8 = OH, benzyloxy, at least 6C alkoxy or NR6R7; R1, R2 = 3-8C cycloalkyl (or linear or branched at least 10C alkyl or (opt. substd. by 3-8C cycloalkyl or 6-10C aryl opt. substd. by up to 3 of halogen, CN, NO2 or OR9); R9 = H or a hydroxy-protecting gp.; Y = NHR10 or at least 8C linear or branched alkyl opt. substd. by pyridyl or phenyl; and R10 = 3-8C cycloalkyl.