PRODUCTION OF GRANULAR CYSTEAMINE HYDROCHLORIDE

PURPOSE:To obtain the title compound producing a small amount of fine powder by reacting hydrogen sulfide with ethyleneimine, then with hydrochloric acid to form cysteamine hydrochloride, melting this compound at a specific temperature and cooling a specific method. CONSTITUTION:Hydrogen sulfide is reacted with ethyleneimine by continuously adding ethyleneimine to hydrogen sulfide maintained under 0-10kg/cm G at 0-10 deg.C in a solvent such as methanol and then heated to remove hydrogen sulfide. Hydrochloric acid is added to the reaction solution, which is cooled to precipitate crystal. The crystal is filtered in an N2 atmosphere, separated and melted by heating to >=60 deg.C. Then the prepared cysteamine hydrochloride is dripped on a corrosion-resistant substrate such as Teflon cooled to