ANTIBIOTIC SUBSTANCE GALACARDINS A AND B

PURPOSE:To obtain an antimicrobial agent for infectious diseases caused by Gram-positive bacteria by culturing a microorganism, belonging to actinomyces and capable of producing galacardins A (G-A) and B (G-B). CONSTITUTION:An antibiotic substance galacardin A produced by culturing a strain SANK 642...

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Hauptverfasser:	INUKAI MASATOSHI, TAKEUCHI MICHIKO, ENOKIDA RYUZO, KAGASAKI TAKESHI, NAGAKI HIDEMI, TAKAHASHI HIDEJI
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PURPOSE:To obtain an antimicrobial agent for infectious diseases caused by Gram-positive bacteria by culturing a microorganism, belonging to actinomyces and capable of producing galacardins A (G-A) and B (G-B). CONSTITUTION:An antibiotic substance galacardin A produced by culturing a strain SANK 64289 (FERM P-10940) in a culture medium containing glucose, etc., providing a culture, centrifuging and purifying the resultant culture and having the following physico-chemical properties. Properties of the substance; amphoteric water-soluble white powder. Specific rotatory power [alpha]-38.7 deg. (c, 1.00, H2O). Elementary analysis value%; C, 50.55; H, 5.62; N, 5.06; Cl, 2.39; F, 1.16 (provided that trifluoroacetic acid and water are partially contained). Molecular formula; C101H121O46N9Cl2. Molecular weight; 2265 (measured by an FAB- MAS method). Hydrolysis; producing monodechlorovancomycinic acid, etc., as amino acids by acid hydrolysis. Ultraviolet absorption spectrum; lambdamaxnm (E) 280nm (39.6). Soluble in water, methanol, etc. The galacardin B is similarly produced. The resultant G-A and G-B, as necessary, contained to produce an antimicrobial agent.