JPH0379335B
Novel N-benzylamides of the general formula in which R1 denotes a hydrogen, fluorine, chlorine or bromine atom, a nitro group, an alkyl or alkoxy group, R2 denotes an aryl group having 6 to 10 carbon atoms, which is optionally mono- or disubstituted by halogen atoms, by alkyl, hydroxyl, alkoxy, phen...
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Hauptverfasser: | , , , , , , |
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Format: | Patent |
Sprache: | eng |
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Zusammenfassung: | Novel N-benzylamides of the general formula in which R1 denotes a hydrogen, fluorine, chlorine or bromine atom, a nitro group, an alkyl or alkoxy group, R2 denotes an aryl group having 6 to 10 carbon atoms, which is optionally mono- or disubstituted by halogen atoms, by alkyl, hydroxyl, alkoxy, phenylalkoxy, alkylsulphenyl, alkylsulphinyl and/or alkylsulphonyl groups, where the substituents can be identical or different, or a heteroaryl group having 4, 5, 8 or 9 carbon atoms and containing 1 or 2 nitrogen atoms, R3 denotes a hydrogen or halogen atom, A denotes an unbranched alkyleneimino group having 4 to 6 carbon atoms, which can be substituted by one or two alkyl groups, or an octahydroazocino, octahydro-1H-azonino or decahydroazecino group, a dialkylamino group, an allyloxy group or an alkoxy group and W denotes a carboxyl, formyl, hydroxymethyl, nitro, cyano, aminocarbonyl, 2-hydroxycarbonylethylene, 2-hydroxycarbonylethyl or 2,2-bis(hydroxycarbonyl)ethyl group, an alkoxycarbonyl group, an ethylene group which is substituted in the 2-position by an alkoxycarbonyl group or an ethyl group which is substituted in the 2-position by one or two alkoxycarbonyl groups, and their salts which have useful pharmacological properties, in particular a hypoglycaemic action. The compounds of the formula I can be prepared by processes customary for analogous compounds. |
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