NEW 2-OXO-1-OXA-8-AZASPYRO (4, 5)DECANE DERIVATIVE, DRUG COMPOUND CONTAINING SAID DERIVATIVE AND THEIR PREPARATION

The invention relates to 2-oxo-1-oxa-8-azaspiro[4,5]decane derivatives of formula (I), wherein X represents oxygen or >NR , wherein R represents hydrogen or alkyl, cycloalkyl or tosyl , or carbocyclic aryl or carbocyclic aryl-alkyl optionally substituted on the aromatic ring by one or more halogen atoms, alkyl, alkoxy or trihalomethyl ; R and R together represent methylene or, when X is a >NR , one of R and R may additionally represent hydroxyl whilst the other one is a methyl ; and R represents hydrogen or benzyl, (alkoxy)carbonyl, phenoxycarbonyl, formyl, piperidin-1-ylcarbonyl, morpholin-4-ylcarbonyl, 4-methylpiperazin-1-ylcarbonyl, 4-(2-hydroxyethyl)piperazin-1-ylcarbonyl, 2-chloro-3-nicotinoylcarbamoyl or alkylcarbamoyl , and optical isomers and mixtures thereof and all acid addition and quaternary ammonium salts thereof, to pharmaceutical compositions containing these compounds and processes for their preparation. The compounds of formula (1) possess anticonvulsive, antiallergic and lipid level lowering effects. Thus, they appear useful for the treatment of epileptic and allergic diseases and increased lipid levels.