JPH036147B

PCT No. PCT/DE81/00031 Sec. 371 Date Oct. 6, 1981 Sec. 102(e) Date Oct. 6, 1981 PCT Filed Feb. 5, 1981 PCT Pub. No. WO81/02296 PCT Pub. Date Aug. 20, 1981.Prostacyclin derivatives of the formula I wherein R1 is OR3 wherein R3 is hydrogen or alkyl of 1-10 carbon atoms, or R1 is NHR4 wherein R4 is alkanoyl or alkanesulfonyl, B is alkylene of 1-5 carbon atoms, A is -CH2-CH2-, cis-CH=CH-, or trans-CH=CH-, W is hydroxymethylene or wherein the OH-group is optionally substituted by alkanoyl of 1-4 carbon atoms and the free or substituted OH-group can be in the alpha - or beta - position, R2 is alkyl of 1-6 carbon atoms optionally substituted by phenyl, or R2 is phenyl, R5 is hydroxy optionally substituted by alkanoyl of 1-4 carbon atoms, R6 is hydrogen, fluorine, or alkyl of 1-4 carbon atoms or when R3 is hydrogen, a salt thereof with a physiologically compatible base, have pharmacological activity e.g., blood pressure-lowering and bronchodilatory effects.