JPH0350755B
NEW MATERIAL:A compound shown by the formula I (R , R , and R are lower alkyl; X and X are H, OH or methoxy; Y is H, OH, or methoxy; Y is H, or OH:Z is H, or protected OH). EXAMPLE:7-Trimethylsilyl-4-demethoxydaunomycin. USE:An intermediate for synthesizing adriamycin, a carcinostatic agent, and its...
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| creator | TERAJIMA ATSURO ABE RUMIKO SUZUKI MICHO MATSUMOTO MITSUYO KIMURA YOSHIICHI |
| description | NEW MATERIAL:A compound shown by the formula I (R , R , and R are lower alkyl; X and X are H, OH or methoxy; Y is H, OH, or methoxy; Y is H, or OH:Z is H, or protected OH). EXAMPLE:7-Trimethylsilyl-4-demethoxydaunomycin. USE:An intermediate for synthesizing adriamycin, a carcinostatic agent, and its analogues. PREPARATION:A compound shown by the formula II is reacted with a ketene silyl acetal shown by the formula III (R and R are lower alkyl) or 1,3-diketone silyl enol ether shown by the formula IV (R and R are lower alkyl) in a solvent such as methylene chloride, ether, etc. at -20-20 deg.C, to give a compound shown by the formula I . |
| format | Patent |
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EXAMPLE:7-Trimethylsilyl-4-demethoxydaunomycin. USE:An intermediate for synthesizing adriamycin, a carcinostatic agent, and its analogues. 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EXAMPLE:7-Trimethylsilyl-4-demethoxydaunomycin. USE:An intermediate for synthesizing adriamycin, a carcinostatic agent, and its analogues. PREPARATION:A compound shown by the formula II is reacted with a ketene silyl acetal shown by the formula III (R and R are lower alkyl) or 1,3-diketone silyl enol ether shown by the formula IV (R and R are lower alkyl) in a solvent such as methylene chloride, ether, etc. at -20-20 deg.C, to give a compound shown by the formula I .</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| title | JPH0350755B |
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