ALPHA-ALPHA-TREHALOSE DERIVATIVE

NEW MATERIAL:A compound expressed by formula I [one to four of R to R are 1-40C aliphatic acyl groups and the rest are H; when one is the aliphatic acyl group, it is not 2-palmitoyl or 6-aliphatic acyl group; when two are aliphatic acyl groups, they are not mutually at positions of the corresponding...

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Bibliographische Detailangaben
Hauptverfasser:	OZEKI HIROMI, YOSHINAGA JUNJI, MASAGAKI TAKESHI, KAKITA TAKAO, KATO TAKAYOSHI
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	NEW MATERIAL:A compound expressed by formula I [one to four of R to R are 1-40C aliphatic acyl groups and the rest are H; when one is the aliphatic acyl group, it is not 2-palmitoyl or 6-aliphatic acyl group; when two are aliphatic acyl groups, they are not mutually at positions of the corresponding numbers; when three are the aliphatic acyl groups, they are not 2,3,2'-tripalmitoyl and when four are the aliphatic acyl groups, they are neither mutually at positions of the corresponding numbers nor at the 2,3,4,2'- or 2,3,6,2'-positions]. EXAMPLE:2-O-(9,10-Epoxystearoyl)-alpha,alpha-trehalose. USE:An antitumor agent with high safety. PREPARATION:alpha,alpha-Trehalose expressed by formula II is initially protected to provide a compound expressed by formula III (Ra to Rc are bifunctional OH-protecting groups), which is then acylated in the presence of a base in an inert solvent to afford a compound expressed by formula IV. The resultant compound expressed by formula IV is subsequently deprotected.