JPH0331196B

JPH0331196B

The invention relates to new 1-[6-(2'-substituted-5', 6', 7', 8'-tetrahydro-4'-oxo-quinazolino)]-3,4-dihydro-6,7-disubstituted-isoqu inoline derivatives of the formula (I) (I) wherein R1 and R2 each independently represents hdyroxyl or alkoxy having from 1 to 6 carbon a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: YANOSHU RAZARU, GABORU BERUNATO, EBA PAROSHI, RASURO SUHORUNII, EREMERU EZERU, JORUJII HAYOSHU, GABORU MOTEIKA, IENEE KOBORU, RASURO DENESHU
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The invention relates to new 1-[6-(2'-substituted-5', 6', 7', 8'-tetrahydro-4'-oxo-quinazolino)]-3,4-dihydro-6,7-disubstituted-isoqu inoline derivatives of the formula (I) (I) wherein R1 and R2 each independently represents hdyroxyl or alkoxy having from 1 to 6 carbon atoms, R3 is alky having from 1 to 6 carbon atoms, optionally substituted phenyl, optionally substituted alkylphenyl having from 1 to 4 carbon atoms in the alkyl moiety or an optionally substiutted heterocyclic group, and acid addition and quaternary salts thereof. Compounds of the formula (I) are pharmaceutically active, in particular show spasmolytic, analgesic, antipyretic activity and have a protecting effect in acute alcoholic intoxication.