SYNTHETIC GLYCOLIPID-SPECIFIED MONOCLONAL ANTIBODY

NEW MATERIAL:A monoclonal antibody capable of recognizing a glycolipid derivative expressed by the formula. USE:A detecting reagent for cancer-related saccharide chain antigens and treating agent for cancer. PREPARATION:For example, the glycolipid derivative expressed by the formula is adsorbed in a...

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Hauptverfasser: HARA KAZUTOSHI, NAKANO KOICHI, KATSUURA KIMIO, KANAKI REIJI, HORIE RYUICHI
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creator HARA KAZUTOSHI
NAKANO KOICHI
KATSUURA KIMIO
KANAKI REIJI
HORIE RYUICHI
description NEW MATERIAL:A monoclonal antibody capable of recognizing a glycolipid derivative expressed by the formula. USE:A detecting reagent for cancer-related saccharide chain antigens and treating agent for cancer. PREPARATION:For example, the glycolipid derivative expressed by the formula is adsorbed in an emulsion of monophosphoryl-lipid A and dimycolic acid trehalose and repeatedly administered into the abdominal cavity of BALB/c mouse for immunization. After the final immunization, splenic cells are recovered and then fused to mouse myelomatous cells using polyethylene glycol, etc., and a clone capable of producing an antibody specifically binding to the glycolipid derivative expressed by the formula is selected from the produced hybridoma according to the Kohler method, etc., and cloned by a limiting dilution method, etc., to provide a cloned hybridoma. The resultant hybridoma is subsequently cultured to afford the objective monoclonal antibody capable of recognizing the glycolipid derivative expressed by the formula.
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recordid cdi_epo_espacenet_JPH03280894A
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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES USING MICROORGANISMS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
TESTING
VINEGAR
WINE
title SYNTHETIC GLYCOLIPID-SPECIFIED MONOCLONAL ANTIBODY
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