NEW CEPHALOSPORIN COMPOUND AND ITS MANUFACTURE

The present invention relates to new cephalosporin compounds of the formula (I), pharmaceutically acceptable non-toxic salts thereof, and physiologically hydrolyzable esters and solvates thereof, which have potent and broad antibacterial activities wherein R is a C1 SIMILAR 4 alkyl, C3 SIMILAR 4 alk...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HAYASHI SHIYOUSAN, NIN MASATAMA, KIN YOUCHIYUU, KIN GENSHIYOU, GO KEISHIYOU, YO ZAIKOU, HOU SANSHIYOKU
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to new cephalosporin compounds of the formula (I), pharmaceutically acceptable non-toxic salts thereof, and physiologically hydrolyzable esters and solvates thereof, which have potent and broad antibacterial activities wherein R is a C1 SIMILAR 4 alkyl, C3 SIMILAR 4 alkenyl, C3 SIMILAR 4 alkynyl group or -C(R)(R)CO2H, wherein R and R are the same or different, and each is a hydrogen atom or a C1 SIMILAR 4 alkyl group, or R and R form a C3 SIMILAR 7 cycloalkyl group with the carbon atom to which they are linked; R is a C1 SIMILAR 4 alkyl, C3 SIMILAR 4 alkenyl or C3 SIMILAR 4 cycloalkyl group, a substituted or unsubstituted amino group, or a substituted or unsubstituted phenyl group; R is hydrogen or a C1 SIMILAR 4 alkyl group, and Q is N or CH; The invention further relates to a process for preparing said compounds, and to pharmaceutical compositions containing said compounds.