DERMAL MEDICAL CARE SYSTEM SHOWING HIGHLY ACTIVE MATERIAL FLOW AND ITS MANUFACTURE
PURPOSE: To provide the subject medical device, comprising an active substance- impermeable backing layer, an active substance-containing matrix of a specific constitution and a water access controlling layer and capable of stably storing the active substance. CONSTITUTION: This transdermal medical...
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Zusammenfassung: | PURPOSE: To provide the subject medical device, comprising an active substance- impermeable backing layer, an active substance-containing matrix of a specific constitution and a water access controlling layer and capable of stably storing the active substance. CONSTITUTION: This transdermal medical delivery device manifests a layer structure having a backing layer 11 without any practical permeability to an active substance, a matrix 12 composed of a basic substance 15, permeable to water vapor but practically insoluble in water and an islandlike part 14 composed of a water-soluble or a water-swellable basic substance containing the active substance distributed therein in the form of a solid solution therein (e.g. PVA, polyvinylpyrrolidone or a polysaccharide) and a layer 13, facing to skin and capable of controlling the access of a liquid in the skin. The particle size of the islandlike part is 5-20μm at the maximum, preferably |
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