TRIAZOLO DERIVATIVE, ITS PREPARATION, ANTI- ANGINAL AGENT OR ATARAXIC AND SEDATIVE COMPOSITION CONTAINING SAID DERIVATIVE AS ACTIVE COMPONENT AND ITS PREPARATION

This invention relates to novel triazolo derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said triazolo derivatives for the treatment of diseases and also for the preparation of pharmaceutical compositions suitable for the treatme...

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Hauptverfasser: ENIKOEE SHIRUTO NEEE KISERI, ISHIYUTOWAAN GACHIYAARII, FURIJIESHIYU GERUJIEENI, KURAARA REITERU NEEE ESHIETSUSHIYU, ISHIYUTOWAAN JIERUCHIYAAN, MAARUTON FUEKETE, GAABORU JIGURERU, YOOJIEFU REITERU, RUIZA PETOEETSU, YOOJIEFU BARUKOOTSUI
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Sprache:eng
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Zusammenfassung:This invention relates to novel triazolo derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said triazolo derivatives for the treatment of diseases and also for the preparation of pharmaceutical compositions suitable for the treatment of the said diseases. The new triazolo derivatives of the general formulae (Ia) and (Ib), wherein Q represents hydrogen or a heterocyclic group optionally bearing one or more C1-4 alkyl substituent(s); or a group of the formula SR , wherein R stands for straight or branched chained C1-4 alkyl or phenyl-(C1-4 alkyl); or a group of the formula NR R , wherein R and R each represent hydrogen, straight or branched chained C1-12 alkyl, C2-6 alkenyl or phenyl-(C1-4 alkyl); R and R each represent hydrogen, C1-6 alkyl or phenyl-(C1-4 alkyl) optionally bearing one or more halogen substituent(s); R and R each stand for C1-4 alkyl optionally substituted by a C1-4 alkoxycarbonyl group; a heterocyclic group or a phenyl group optionally bearing one or more halogen, hydroxyl, cyano, nitro, di-(C1-4 alkyl)-amino or C1-4 alkoxy substituent(s) which latter may carry a di-(C1-4 alkyl)-amino group; furthermore one of R and R may represent hydrogen, or R and R together stand for C4-15 alkylene, or together with the adjacent carbon atom they are attached to form a heterocyclic group bearing a phenyl-(C1-4 alkyl) substituent, possess valuable antianginal and tranquillant/sedative properties and are useful in therapy.