PRODUCTION OF ENEYNE DERIVATIVE

PURPOSE:To obtain the subject compounds useful as a fungicide, etc., in a mild reaction condition in a high yield and at a low cost without using a special apparatus by reacting a new substituted allylamine derivative with a substituted acetylene derivative in the presence of Pd catalyst. CONSTITUTION:A compound of formula I (W is halogen; Z is eliminative group) is reacted with an amine of formula II [R is H, alkyl, haloalkyl, alkenyl, etc.; R is H, formula III (R is H or alkyl; R is H, OH, alkyl, etc.), etc.] to obtain a new substituted allylamine of formula IV. The resultant new compound is reacted with an acetylene derivative of formula V (R is H, alkyl, phenyl, etc.) in the presence of Pd catalyst to obtain a compound of formula VI. N-alkylation is further carried out as necessary, thus obtaining the objective eneyne derivative of formula VII (R is H, alkyl, alkenyl, etc.; R is formula III, etc.). The resultant compound is useful as a fungicide, a compound capable of selective inhibition of squalene epoxydase and having a remarkable anticholesterol effect and a precursor thereof.