NICOTINE-CONTAINING CATAPLASM FOR ORAL CAVITY MEMBRANE

PURPOSE:To provide the titled cataplasm useful for the therapies for nicotine- toxic patients, made up of a tacky layer adhesive to the oral cavity mucous membrane and a nicotine-contg. substrate layer thereon. CONSTITUTION:Firstly, a tacky layer is prepared by dispersing a water-soluble polymer (e.g. polyvinyl alcohol) and water-insoluble polymer (e.g. ethyl cellulose) and/or water-swellable polymer with 1-50wt.% of nicotine or its salt and, if needed, organic acid and/or basic substance followed by pH adjustment. Thence, this tacky layer is made to adhere to a substrate layer adhesive to the oral cavity mucous membrane, thus obtaining the objective cataplasm. The contents of the respective polymers in the layers are as follows: (1) the water-soluble polymer: 20-80wt.% (in the tacky layer); (2) the water-swellable and/or water- insoluble polymer: 1-70wt.% (in the tacky layer) and 50-90wt.% (in the substrate layer). The present cataplasm can administer the nicotine to the oral cavity mucous membrane quantitatively and substainedly.