HEATING TREATMENT OF MONOCLONAL ANTIBODY-CONTAINING AQUEOUS SOLUTION

PURPOSE:To deactivate the virus contained in the title solution without degrading the activity of the antibody by heating treatment of a monoclonal antibody- contg. aqueous solution in the presence of sorbitol. CONSTITUTION:An aqueous solution partially purified or being in the process of purificati...

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Bibliographische Detailangaben
Hauptverfasser:	KANO YOSHIAKI, KAMIMURA YATSUHIRO, GOTO SETSU
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PURPOSE:To deactivate the virus contained in the title solution without degrading the activity of the antibody by heating treatment of a monoclonal antibody- contg. aqueous solution in the presence of sorbitol. CONSTITUTION:An aqueous solution partially purified or being in the process of purification, containing monoclonal antibody, esp. chimeral antibody, and pref. also containing 1-30% (W/V) of protein and being at a pH of 5-6, is incorporated with 10-70 (pref. 40-60)g., per 100ml of the solution, of sorbitol followed by heating treatment at 50-70 deg.C for 10-20min (pref. at 60 deg.C for 10hr) at an ionic strength of