PYRIDONECARBOXYLIC ACID DERIVATIVE

PYRIDONECARBOXYLIC ACID DERIVATIVE

NEW MATERIAL:The compound of formula I [R is lower alkyl or (F- substituted) phenyl; R is H or lower alkyl; X is N or C-Y (Y is H, halogen, methyl or methoxy)]. EXAMPLE:1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(trans-2-oxa-5,8- diazabicyclo[4,3,0]nonan-8-yl)-4-oxo-3-quinolinecarboxylic acid. USE:An...

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Bibliographische Detailangaben
Hauptverfasser: MANO EIICHI, USHIJIMA RYOSUKE, NAKAGAWA SUSUMU
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:NEW MATERIAL:The compound of formula I [R is lower alkyl or (F- substituted) phenyl; R is H or lower alkyl; X is N or C-Y (Y is H, halogen, methyl or methoxy)]. EXAMPLE:1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(trans-2-oxa-5,8- diazabicyclo[4,3,0]nonan-8-yl)-4-oxo-3-quinolinecarboxylic acid. USE:An antibacterial agent against Gram-positive bacteria, Gram-negative bacteria, etc. PREPARATION:A compound of formula II (R is H or carboxyl-protecting group; Z is eliminable group) or its salt is made to react with a compound of formula III (R is H, amino-protecting group or lower alkyl) usually in an inert solvent such as ethanol preferably at 80-150 deg.C for 1-6hr and, a necessary, removing the protecting group from the resultant compound of formula IV.