JPH0314292B

PURPOSE:The titled pharmaceutical, containing a substance FK-565, and capable of enhancing further the physiological activity. CONSTITUTION:A pharmaceutical, containing liposome, and prepared by dissolving a natural phospholipid, e.g. egg yolk lecithin, soybean lecithin or sphingomyelin or phosphatidyl serine, or a synthetic phospholipid, e.g. distearoylphosphatidyl choline or dipalmitoylphosphatidyl choline, capable of forming a liposome membrane, in an organic solvent, e.g. chloroform, introducing the resultant solution into a suitable vessel, distilling away the solvent under reduced pressure, forming a thin membrane on the inner surface of the vessel, introducing an aqueous solution of a substance FK-565 thereinto, and shaking or treating the resultant mixture with ultrasonic waves to give a suspension of the liposome (fine particles). The resultant liposome can be isolated by means of centrifugation, etc. The substance FK-565 has the antitumor and phylactic action.