ANTITUMOR AGENT CONTAINING ANTITUMOR POLYSACCHARIDE ORIGINATED FROM POLYPORUS CONFLUENS AS ACTIVE COMPONENT AND PRODUCTION THEREOF

PURPOSE:To obtain an antitumor agent effective even to an animal having histocompatibility antigen H-2 by culturing Polyporus confluens in a liquid medium, subjecting the culture liquid to hot-extraction, sterilization and alcohol treatment and using the obtained purified polysaccharide as an active...

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Hauptverfasser:	SHIMURA KEISHIRO, ITO HITOSHI, MIZUNO TAKU, NARUSE SENSUKE, SUMITANI TOSHIMITSU
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS THEIR PREPARATION OR CHEMICAL WORKING-UP VINEGAR WINE
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Zusammenfassung:	PURPOSE:To obtain an antitumor agent effective even to an animal having histocompatibility antigen H-2 by culturing Polyporus confluens in a liquid medium, subjecting the culture liquid to hot-extraction, sterilization and alcohol treatment and using the obtained purified polysaccharide as an active component. CONSTITUTION:Culture liquid produced by culturing Polyporus confluens in a liquid medium is extracted at 100 deg.C for 4hr, sterilized and treated with an alcohol. The precipitate is washed with an alcohol and freeze-dried to obtain a polysaccharide [beta-(1 3)-D-glucan having N-PS: beta-(1 6) branch]. The polysaccharide is oxidized with periodic acid and separated into a supernatant fraction (1) and a gel fraction (2). The supernatant fraction (1) is reduced with NaBH4 to obtain a polysaccharide (N-PS.polyol). The gel fraction (2) is further oxidized with periodic acid and separated into a supernatant fraction (1') and a gel fraction (2'). The gel fraction (2') is reduced with NaBH4 to obtain a polysaccharide (N-PS.polyol gel).