NOVEL CNS-ACTIVE HEXAPEPTIDE HAVING ANTI- FORGETFULNESS ACTION

The present invention relates to hexapeptides of the general formula I R -A -A -A -A -A -A -NH(CH2)n-NH2 (I> where R denotes Z, formyl or (subst.) alkanoyl; A denotes Met, Met(O) or Met(O2), all of which can be in the L or D form; A denotes Glu, D-Glu, Ala or pyroglutamyl; A denotes His, Ala, Phe...

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Bibliographische Detailangaben
Hauptverfasser:	GEORUKU IEEGAA, FURANTSU HOTSUKU, HERUMAN YOOZEFU GEERUHARUTSU
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to hexapeptides of the general formula I R -A -A -A -A -A -A -NH(CH2)n-NH2 (I> where R denotes Z, formyl or (subst.) alkanoyl; A denotes Met, Met(O) or Met(O2), all of which can be in the L or D form; A denotes Glu, D-Glu, Ala or pyroglutamyl; A denotes His, Ala, Phe or D-Lys; A denotes the radical of a neutral aliphatic or aromatic alpha -amino acid; A denotes Lys or D-Lys; A denotes (subst.) Phe and n denotes an integer from 4 to 10. Processes for the preparation thereof, the use thereof as medicines, and pharmaceutical compositions containing these are described.