JPH029028B

JPH029028B

PURPOSE:To obtain the titled compound useful as a drug in high yield, by acylating L-carnosine with an acyl donor under specific conditions. CONSTITUTION:L-Carnosine is acylated with an acyl donor such as carboxylic acid anhydride, etc. shown by the formula (RCO)2O or RCOCl (R is alkyl, etc.) under...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: EGUCHI ARAHIKO, KAKIZAKI FUSAYOSHI, ETO HIROZUMI
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:PURPOSE:To obtain the titled compound useful as a drug in high yield, by acylating L-carnosine with an acyl donor under specific conditions. CONSTITUTION:L-Carnosine is acylated with an acyl donor such as carboxylic acid anhydride, etc. shown by the formula (RCO)2O or RCOCl (R is alkyl, etc.) under basic conditions in an alkali aqueous medium (e.g., sodium hydroxide, etc.) with keeping pH 9-13.5 and the reaction temperature at about 5-25 deg.C, to give the desired compound. An inorganic base, etc. such as NaOH, etc. is used for the basic conditions. EFFECT:Racemization and side reactions caused by the acylation of N on the imidazole nucleus in histidine are completely suppressed.