NOVEL PRODUCTION OF CEPHEM PRODRUG ESTER

The invention relates to a process for the preparation of a physiologically hydrolyzable ester of formula I wherein R is hydrogen, R is hydrogen or methyl, and R is a physiologically hydrolyzable ester group which comprises (1) providing an O-protected acid of Formula I wherein R is hydrogen and R i...

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Bibliographische Detailangaben
Hauptverfasser:	OKUYAMA SATSUKI, NAITO TAKAYUKI, GAMACHI HAJIME, OKITA TAKAAKI
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Beschreibung
Zusammenfassung:	The invention relates to a process for the preparation of a physiologically hydrolyzable ester of formula I wherein R is hydrogen, R is hydrogen or methyl, and R is a physiologically hydrolyzable ester group which comprises (1) providing an O-protected acid of Formula I wherein R is hydrogen and R is an O-protecting group of the type commonly used in the synthesis of cephalosporin compounds, and R is as defined above; (2) introducing the said R physiologically hydrolyzable ester group; and (3) replacing said R O-protecting group with hydrogen.