IMIDAZOLE DERIVATIVE

The invention relates to imidazole derivatives of the general formula (I) wherein Im represents an imidazolyl group of formula: A represents the group CH or a nitrogen atom; R and R , which may be the same or different, and may be attached to either the same or different fused rings of the naphthalene moiety, each represents a hydrogen atom, a halogen atom, or a hydroxy, C1-4alkoxy, C1-4alkyl or C1-4alkylthio group, and one of R and R may also represent a group -NR R (wherein R and R , which may be the same or different, each represents a hydrogen atom or a C1-4alkyl group, or together with the nitrogen atom to which they are attached form a saturated 5 to 7 membered ring); n represents 1, 2 or 3; one of the groups represented by R , R and R , is a hydrogen atom or a C1-6alkyl, C3-7cycloalkyl, C3-6alkenyl, phenyl or phenylC1-3alkyl group, and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C1-6alkyl group; and physiologically acceptable salts and solvates thereof. The compounds are potent and selective antagonists of the effect of 5-HT at 5-HT3 receptors and are useful, for example, in the treatment of psychotic disorders, anxiety, and nausea and vomiting.