JPH0229679B

JPH0229679B

NEW MATERIAL:A 4-hydroxy-2-methyl-N-(6-halogeno-2-pyridyl)2H-thieno[2,3-e]- 1,2-thiazine-3-carboxyamido 1,1-dioxide shown by the formulaI(X is halogen) or its salt with an inorganic or organic base. USE:An antiphlogistic agent. Having low toxicity and low digestive tube disorder. PROCESS:For example...

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Hauptverfasser: OKAZAKI YUTAKA, AWAYA AKIRA, SAKANO ISAO, KAWAMO HIROSHI, KITANO TAKASHI, MATSUBARA AKIRA, KUMAKURA MIKIO, KOBAYASHI HIDEYA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:NEW MATERIAL:A 4-hydroxy-2-methyl-N-(6-halogeno-2-pyridyl)2H-thieno[2,3-e]- 1,2-thiazine-3-carboxyamido 1,1-dioxide shown by the formulaI(X is halogen) or its salt with an inorganic or organic base. USE:An antiphlogistic agent. Having low toxicity and low digestive tube disorder. PROCESS:For example, an ester (e.g., 3-carbomethoxy-4-hydroxy-2-methyl-2H- thieno[2,3-e]-1,2-thiazine 1,1-dioxide, etc.) shown by the formula II (R is 1-4C alkyl) is reacted with an aminopyridine (e.g., 2-amino-6-chloropyridine, etc.) shown by the formula III in an inert high-boiling solvent such as xylene, etc. at >=100 deg.C for 8-20hr.