NOVEL PRODUCTION OF IMIDAZOPYRIDINE DERIVATIVE

PURPOSE:To obtain the title compound having inhibitory action on secretion of acid in the stomach and antitumor activity readily and in high yield by reacting an aminopyridine ether with an acrylic acid derivative as raw materials and reacting the reaction product with ammonia and then with a dehydrating agent. CONSTITUTION:An aminopyrdine ether shown by formula I (R is alkyl which may be replaced with cycloalkyl group or 4-6C alkenyl) is reacted with an acrylic acid derivative shown by formula II (R and R are lower alkyl) in equimolar amounts or somewhat an excess amount of one compound at room temperature-under heating in a solvent such as ethanol to give a 3-lower alkoxycarbonylmethylimidazopyridine derivative shown by formula III. Then this compound is reacted with ammonia to give a 3- carbamoylmethylimidazopyridine derivative shown by formula IV, which is successively reacted with somewhat an excess amount of a dehydrating agent such as phosphorus pentachloride under cooling-room temperature to give a compound shown by formula V.