NOVEL STEROID DERIVATIVES, PHARMACEUTICAL COMPOSITES CONTAINING THEM AND METHOD FOR PREPARATION THEREOF

The invention relates to novel DELTA -16 alpha ,17-dihydroxy-pregnane-16,17-cyclic aldehyde acetal and -cyclic ketone ketal derivatives of general formula (I), wherein A stands for hydrogen or hydroxyl group; X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means hydrogen; R stands for hydrogen,benzoyl or C18alkanoyl group; R and R , which are the same or different, stand for hydrogen or a C14alkyl group; or one of R and R is hydrogen and the other is phenyl group; or R and R together form a C45alkylene group; --- means a single or double bond between two adjacent carbon atoms, as well as pharmaceutical compositions containing these compounds and a process for their preparation. The compounds of general formula (I) possess a very strong antiinflammatory effect and only week harmful side effect. Thus, they can be used as active ingredients of antiinflammatory pharmaceutical compositions being useful in the therapy.