HIV TRANSACTIVATOR TARGET ARRANGEMENT (TAR) FROM I AND ANTISENSE OLIGONUCLEOTIDES FOR INHIBITING SYNTHESIS OF TRANSACTIVATOR PROTEIN (TAT) AND USE THEREOF

The present invention relates to chemically modified antisense oligonucleotides for inhibiting the transactivator target sequence (TAR) and the synthesis of the transactivator protein (tat) of HIV-1 and to the use thereof in pharmaceuticals. The chemically modified antisense oligonucleotides have an...

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Bibliographische Detailangaben
Hauptverfasser:	HAINTSU KERUPURU, BERUNAA FUROMAA, UDO SHIYUTOROTSUPU, IERUKU BAUMUGARUTEN, ANTONIUSU REBERUDEINGU, NORUBERUTO PIIRU, BORUFUGANGU SHIYUPURINGAA, AKUSERU KURECHIYUMAA
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to chemically modified antisense oligonucleotides for inhibiting the transactivator target sequence (TAR) and the synthesis of the transactivator protein (tat) of HIV-1 and to the use thereof in pharmaceuticals. The chemically modified antisense oligonucleotides have antiviral effects. The pharmaceuticals can be used for the therapy of HIV infections. The antisense oligonucleotides are suitable as gene probes for detecting HIV.