IMPROVER FOR DYSMNESIA

PURPOSE:To obtain an improver for dysmnesia, containing a specific amide compound or acid addition salt thereof as an active ingredient and having excellent acetylcholine esterase inhibitory action. CONSTITUTION:An improver containing a compound expressed by the formula [R1 to R3 are H, alkyl, alkox...

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Hauptverfasser:	OGAWA NOBUO, ECCHU EIICHI, MORIKAWA KOJI, ITO YASUO, OSHITA MASAFUMI, KATO HIDEO
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	OGAWA NOBUO ECCHU EIICHI MORIKAWA KOJI ITO YASUO OSHITA MASAFUMI KATO HIDEO
description	PURPOSE:To obtain an improver for dysmnesia, containing a specific amide compound or acid addition salt thereof as an active ingredient and having excellent acetylcholine esterase inhibitory action. CONSTITUTION:An improver containing a compound expressed by the formula [R1 to R3 are H, alkyl, alkoxy, OH, halogen, NO2, CN, (alkyl-substituted) amino, (alkyl-substituted) sulfamoyl or both together represent methylenedioxy; R4 and R5 are alkyl, cycloalkyl or both together, along with N, represent 1- pyrrolidinyl, 1-piperidinyl, 1-piperazinyl or 1-morpholinyl] or acid addition salt thereof, e.g. N-[4-[2-(dimethylamino)ethoxy]benzyl]-2-ethoxybenzamide hydrochloride, as an active ingredient. The above-mentioned pharmaceutical is extremely useful as an improver for dysmnesia accompanied by Alzheimer type senile dementia or other dementias and the dose thereof for an adult is normally 10-100mg per day.
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CONSTITUTION:An improver containing a compound expressed by the formula [R1 to R3 are H, alkyl, alkoxy, OH, halogen, NO2, CN, (alkyl-substituted) amino, (alkyl-substituted) sulfamoyl or both together represent methylenedioxy; R4 and R5 are alkyl, cycloalkyl or both together, along with N, represent 1- pyrrolidinyl, 1-piperidinyl, 1-piperazinyl or 1-morpholinyl] or acid addition salt thereof, e.g. N-[4-[2-(dimethylamino)ethoxy]benzyl]-2-ethoxybenzamide hydrochloride, as an active ingredient. 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subjects	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	IMPROVER FOR DYSMNESIA
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