PRODUCTION OF 2-HYDROXY-4-PHENYLBUTYRIC ACID

PURPOSE:To obtain readily and in high yield the title compound to be used as an intermediate for angiotensin transferase inhibitor, etc., by heating 3- phenylpropionaldehyde cyanhydrin as raw material in the presence of conc. HCl to effect hydrolysis. CONSTITUTION:3-phenylpropionaldehyde cyanhydrin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	SEGAWA HIROZO, IGARASHI RENSUKE, SHIRAKAWA HIDEO
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	PURPOSE:To obtain readily and in high yield the title compound to be used as an intermediate for angiotensin transferase inhibitor, etc., by heating 3- phenylpropionaldehyde cyanhydrin as raw material in the presence of conc. HCl to effect hydrolysis. CONSTITUTION:3-phenylpropionaldehyde cyanhydrin as raw material is hydrolyzed in the presence of >=35% HCl (pref. conc. HCl) at 40-90 deg.C to obtain the objective 2-hydroxy-4-phenylbutyric acid. It is preferable that an oily matter formed as by-product during the hydrolysis be treated with hydrochloric acid. Or it is preferable that said oily matter be recycled to the hydrolysis process for the 3-phenylpropionaldehyde cyanhydrin. With the present method, the objective compound can be produced in a simple operation in high yield.