DRUG PREPARATION CONTAINING BROMHEXINE HYDROCHLORIDE

PURPOSE:To obtain the subject drug preparation free from the problems of the loss of bromhexine hydrochloride in the preparation caused by the adsorption to packaging material or container during storage and the lowering of the drug action by compounding bromhexine hydrochloride known as an excellent expectorant with a substance having surface activity. CONSTITUTION:The objective preparation can be prepared by compounding bromhexine hydrochloride with a substance having surface activity. The surface- active substance is preferably a sucrose fatty acid ester, glycerol monostearate, a polyethylene glycol fatty acid ester, etc., especially an ionic surfactant such as sodium laurylsulfate. The amount of the surfactant is 1-50pts.wt., especially 2-25pts.wt. per 1pt.wt. of bromhexine hydrochloride. The preparation can be prepared, e.g. in the case of a solid preparation, by mixing bromhexine hydrochloride with an excipient, a binder and a surface-active substance, kneading the mixture with a solvent and sieving the product after drying.