NOVEL 4H-1-BENZOPYRAN-4-ON DERIVATIVE

NEW MATERIAL: A compound of formula I (R1 is H, a 1-6C alkyl, a 3-6C cycloalkyl, etc.; R2 is H, a 1-6C alkyl, an aryl, etc.; R3 is H, a 1-4C alkyl, hydroxyl, etc.; R4 is H, hydroxyl, a 1-4C alkoxy, etc.; R5 is H, a 1-6C alkyl, a 3-6C cycloalkyl, etc.; (m) is 0-3; (n) is 0-2) and an acid-added salt t...

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Bibliographische Detailangaben
Hauptverfasser:	RAMUCHIYANDORA GANAPATEI NAIKU, RIHIARUTO HERUMUUTO RUTSUPU, HANSU HAARARUTO ZETORATSUEKU, BANSHI RARU, GEERUHARUTO DEIKUNAITE, IERUKU TSUETSUKU
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	NEW MATERIAL: A compound of formula I (R1 is H, a 1-6C alkyl, a 3-6C cycloalkyl, etc.; R2 is H, a 1-6C alkyl, an aryl, etc.; R3 is H, a 1-4C alkyl, hydroxyl, etc.; R4 is H, hydroxyl, a 1-4C alkoxy, etc.; R5 is H, a 1-6C alkyl, a 3-6C cycloalkyl, etc.; (m) is 0-3; (n) is 0-2) and an acid-added salt thereof. EXAMPLE: (±)-cis-5,7-dihydroxy-2-(2-thienyl)-8-[4-(3-hydroxy-1-methyl)piperidinyl]-4 H-1-benzopyran-4-one. USE: Antitumor agent, inhibiting kinase or growth factor receptor tyrosine kinase for which oncogene codes. PREPARATION: A compound of formula II is reacted with an alkali metal and an alkyl ester to form the corresponding diketone of formula III, which, in turn, is cyclized by reaction with a mineral acid to obtain the objective compound of formula I.