PYRIMIDO-(6, 1-A)-ISOQUINOLIN-4-ONE DERIVATIVE

PURPOSE: To obtain a medicine preparation having enhancing effects on hair growth and preventing effect on hair loss, containing a pyrimido-(6,1-a)- isoquinolin-4-one derivative. CONSTITUTION: A medicine preparation effective for external use and local treatment is obtained by pharmaceutically manufacturing a compound of the formula (R , R and R are each H, hydroxyl, a lower alkoxy, an acyloxy, a halogen, etc.; R and R are each H, hydroxyl, a lower alkoxy, amino, etc.; R is H, an alkyl, a cycloalkyl, etc.), its acid salt or quaternary ammonium salt as an active ingredient by a conventional method. 9,10-Dimethoxy-2-tertiary butylamino-6,7-dihydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one hydrochloride may be cited as the compound of the formula.