PRODUCTION OF 5,6,7,8-TETRAHYDROISOQUINOLINE

PURPOSE:To obtain the title substance in high yield by catalytically hydrogenating crude coal tar-based isoquinoline to give 1,2,3,4-tetrahydroisoquinoline having reduced sulfur content and then isomerizing 1,2,3,4-tetrahydroisoquinoline in the presence of Ni catalyst such as Raney nickel. CONSTITUT...

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Bibliographische Detailangaben
Hauptverfasser:	TANAKA YASUSHI, SATO TOSHIO, ITO IKUO, TAKAKU SHINJI
Format:	Patent
Sprache:	eng
Schlagworte:	APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	PURPOSE:To obtain the title substance in high yield by catalytically hydrogenating crude coal tar-based isoquinoline to give 1,2,3,4-tetrahydroisoquinoline having reduced sulfur content and then isomerizing 1,2,3,4-tetrahydroisoquinoline in the presence of Ni catalyst such as Raney nickel. CONSTITUTION:Crude coal tar-based isoquinoline is catalytically hydrogenated to give 1,2,3,4-tetrahydroisoquinoline(THIQ) having 0.01-0.3wt.% sulfur content, which is isomerized in the presence of Ni catalyst (e.g., Raney nickel) at 200-300 deg.C under