PRODUCTION OF PIPERIDINE COMPOUND AND SYNTHETIC INTERMEDIATE COMPOUND THEREOF

PURPOSE:To obtain the title compound from a phenyl derivative and piperidine derivative containing a novel substance via three kind of novel intermediates by condensation, reduction, intramolecular ring closure, condensation and deesterification and/or denitrogen protecting group reaction. CONSTITUT...

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Hauptverfasser:	IKEBE TSUGIO, KITAJIMA HIROSHI, MURAKAMI OSAMU
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Beschreibung
Zusammenfassung:	PURPOSE:To obtain the title compound from a phenyl derivative and piperidine derivative containing a novel substance via three kind of novel intermediates by condensation, reduction, intramolecular ring closure, condensation and deesterification and/or denitrogen protecting group reaction. CONSTITUTION:A novel substance expressed by formula 1 (A is CH2, O or S; R is ester residue; R is alkyl capable of having halogen, phenyl or substituted phenyl) is condensed with a compound expressed by formula II (R is ester residue; R is nitrogen protecting group; B is O or S; m is 1 or 2; n is integer of 0-3) or a compound expressed by formula III is condensed with a compound expressed by formula VI to give a novel substance, which is then reduced to give a novel substance expressed by formula VI. Then the novel substance expressed by formula VI is subjected to intramolecular ring closure to afford a novel substance expressed by formula VII, which is then condensed with a compound expressed by the formula XCH2CO2R (R is ester residue; X is halogen) and the condensed product is subjected to deester and/or denitrogen-protecting group reaction to provide the compound expressed by formula VIII useful as angiotensin conversion enzyme-preventing agent, ester thereof or salt thereof.