1-(1H-IMIDAZOL-1-YL)PHTHALAZINE DERIVATIVE

1-(1H-IMIDAZOL-1-YL)PHTHALAZINE DERIVATIVE

NEW MATERIAL:1-(1H-imidazol-1-yl)phthalazine derivative of formula I (Y is-NR-, -O- or -S-; R is 1-10C alkyl, 2-4C alkyl containing hydroxyl group, allyl, 3-methoxypropyl, tetrahydrofurfuryl, furfuryl, benzyl which may be substituted with Cl or alkyl, phenethyl, pyridylmethyl or phenyl which may be...

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Hauptverfasser: TSUKAMOTO ZENJI, YAGINUMA HIDEYA, UENISHI KEIJI, ISHIZUKA YASUHIRO, KOSEGI KOJI, ASAUMI YOSHIO, TAKEHARA HIROYUKI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:NEW MATERIAL:1-(1H-imidazol-1-yl)phthalazine derivative of formula I (Y is-NR-, -O- or -S-; R is 1-10C alkyl, 2-4C alkyl containing hydroxyl group, allyl, 3-methoxypropyl, tetrahydrofurfuryl, furfuryl, benzyl which may be substituted with Cl or alkyl, phenethyl, pyridylmethyl or phenyl which may be substituted with Cl, provided that R is not substituted phenyl nor non-substituted phenyl in case Y is -NH-). EXAMPLE:1-(1H-imidazol-1-yl)-4-(methylamino)phthalazine. USE:Useful as an antithrombotic agent with high safety capable of oral and parenteral administrations. PREPARATION:A reaction is carried out as shown by the reaction formula to obtain the objective compound of formula I.