NOVEL 1ALPHA,25-DIHYDROXYVITAMIN D3 DERIVATIVE AND PRODUCTION THEREOF

NEW MATERIAL:A compound shown by formula I [one of R1 and R2 is OH and the other is -O-CO-R3-NH2 (R3 is 1-10C alkylene) and the title radioisotope compound shown by formula II [one of R1 and R2 is OH and the other is -O-CO- R3-R5 (R3 is 1-10C alkylene; R5 is residue containing radioisotope of iodine...

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Bibliographische Detailangaben
Hauptverfasser:	TANABE MIYUKI, IKUTA SHIGERU
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE TESTING
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Beschreibung
Zusammenfassung:	NEW MATERIAL:A compound shown by formula I [one of R1 and R2 is OH and the other is -O-CO-R3-NH2 (R3 is 1-10C alkylene) and the title radioisotope compound shown by formula II [one of R1 and R2 is OH and the other is -O-CO- R3-R5 (R3 is 1-10C alkylene; R5 is residue containing radioisotope of iodine)]. USE:Determination of 1alpha,25-dihydroxyvitamin D3, an active type in a specimen solution. An antibody prepared by bonding a compound sown by formula I to a carrier protein as a hapten and immunizing and a compound shown by formula II are used. PREPARATION:1alpha,25-dihydroxyvitamin D3 is reacted with an amino acid containing protected amino group, the amino-protecting group is eliminated from the prepared compound to give a compound shown by formula I. Radioactive iodine (preferably I) is labeled with the compound shown by formula I by indirect labeling to give a compound shown by formula II.