PHYSIOLOGICALLY ACTIVE PEPTIDE COMPOSITION FOR NASAL APPLICATION

PURPOSE:To obtain the subject composition containing active component safely and efficiently absorbable through nasal mucosa by compounding a lactone compound of a water-soluble organic acid as an absorbefacient and, as necessary, a diluent to a physiologically active peptide composition. CONSTITUTION:A powdery composition for nasal application containing physiologically active peptides, preferably a peptide hormone having a molecular weight of 1,000-10,000 or its derivative (especially calcitonins, parathyroid hormones or insulins) as active component is incorporated with (A) a lactone compound of a water-soluble organic acid (preferably aldonolactone compound such as gluconolactone or glucuronolactone) as an absorbefacient and, as necessary, further (B) a diluent (preferably mannitol and/or dextran). More than 80% of each component preferably has particle diameters distirbuted within the range of